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Reference:
Vitamin D is not just a bone vitamin. It acts like a hormone + local gene-regulating signal that affects:
*Bone and calcium
*Muscle strength and balance
*Immune function (infections, autoimmunity)
*Metabolic health (diabetes, obesity, cardiovascular disease)
*Pregnancy and infant health
1. Endocrine system
Kidney converts vitamin D to calcitriol (the “active hormone”).
Main job: keep calcium and bone normal.
2. Intracrine / paracrine / genomic system
Immune cells, placenta, and other tissues convert vitamin D inside the cell.
This is how vitamin D influences genes, inflammation, immunity, pregnancy, etc.
15 ng/mL – Bare minimum for calcium metabolism (prevent rickets/osteomalacia).
20 ng/mL – Enough for basic musculoskeletal function: balance, falls, fractures.
30 ng/mL – Better for:
Osteoporosis, fractures
Inflammatory bone disease
Secondary hyperparathyroidism
40+ ng/mL – Linked to lower risk of:
Metabolic disorders (obesity, diabetes)
Cardiovascular disease
Reduced all-cause mortality
50–80 ng/mL – The paper argues this range may be ideal for:
Robust innate and adaptive immune function
Lower risk/severity of infections, sepsis, some cancers
80 ng/mL – Proposed in the paper for certain “vitamin D resistance” states (e.g., some autoimmune or inflammatory conditions), but this is more experimental and definitely specialist-level.
Pregnancy & Breastfeeding
RCTs using 4000 IU/day in pregnancy improved outcomes and were safe.
Maternal levels 40 ng/mL linked to fewer complications and better birth outcomes.
To reach that, the paper suggests 4000–6000 IU/day in pregnancy.
Dr. Jin Sung is a Chiropractic Physician who specializes in the management of complex chronic conditions in Massachusetts, 30 minutes north of Boston. He utilizes natural and alternative therapies to help manage complex cases such as Hashimoto’s, autoimmune conditions, IBS, SIBO, chronic fatigue, brain fog, early Alzheimer’s, etc.
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This video is for general information and educational purposes only and does NOT constitute the practice of medicine or other professional health services, including giving of a medical advice. NO doctor-patient relationship is formed. It should not be used to self-diagnose and it is not a substitute for a medical exam, cure, treatment, diagnosis, and prescription or recommendation. You should not make any change in your health regimen or diet before first consulting a physician. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition.
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