Dr. Perlmutter returns to the Dr. Gundry Podcast to discuss the new data that’s reshaping Alzheimer’s disease treatment. One in nine Americans over age 65 is already diagnosed with dementia—and it’s being called an epidemic. But here’s what’s shocking: a massive analysis of over 20,000 patients across 17 different trials reveals that current FDA-approved dementia drugs are failing—and carrying serious risks that doctors aren’t talking about.
This raises urgent questions: If these drugs aren’t working, what is actually causing dementia and Alzheimer’s disease? And more importantly, what can you actually do about it?
Dr. Gundry and Dr. Perlmutter break down what the research is really showing, why mainstream medicine has gotten this so wrong for so long, and what the actual science says about prevention, cognitive decline, and brain health. You’ll discover the metabolic connection most doctors never mention, why genetic risk factors aren’t destiny, and what your lifestyle choices have to do with your brain’s future.
If you’re concerned about memory loss, cognitive decline, Alzheimer’s risk, or dementia prevention—or if someone you love is—this conversation cuts through the noise and reveals what actually matters.
The answers aren’t what you’ve been told.
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00:00 – Dr. Perlmutter on the Dementia Epidemic and Drug Failure
06:03 – The Gut-Brain Connection Explained
09:20 – Microglial Cell Shifts and Metabolism
15:18 – Lifestyle Interventions for Cognitive Health
18:42 – Mindset, Metabolic Health, and GLP-1s
22:27 – Optimal Diet, Fats, and Sleep
26:22 – Emerging Science and 40Hz Therapy
28:31 – Microtubules, Tau, and p-tau217
31:53 – Alzheimer’s Risk Factors for Women
35:36 – Hormone Replacement and Preventive Care
41:05 – Future Therapies and Immunometabolism Concept
45:44 – Social Connection, Microglia, and Oxytocin
49:44 – Oral Microbiome and Nitric Oxide
53:58 – Periodontal Health and Oral Hygiene
56:57 – Evidence Supporting Lifestyle Changes
01:00:00 – Evaluating New Alzheimer’s Medications
#AlzheimersDisease #DementiaEpidemic #BrainHealth #DrGundry #DrPerlmutter #Prevention #CognitiveDecline #Alzheimers #HealthTruth #Longevity
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