This clip is from episode #374 – The evolutionary biology of testosterone: how it shapes male development and sex-based behavioral differences | Carole Hooven, Ph.D.
In this clip, they discuss:
– Restoring Testosterone to Youthful Levels – Opens by asking whether raising a 55-year-old’s testosterone to age-18 levels carries meaningful downside
– Symptoms Matter More Than Age – The appropriateness of higher testosterone levels depends on symptoms rather than a specific numerical target
– Different Bodies, Same Number – Some men maintain muscle easily even with testosterone in the 20th percentile, while others struggle at similar levels
– The Missing Lab Test – There is currently no assay that measures androgen-receptor density, despite its importance in how testosterone is felt and used in the body
– Receptor Saturation Hypothesis – If symptoms don’t improve at higher testosterone levels, low androgen-receptor density may explain the lack of response
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