Researchers discover a drug combo that may overcome treatment resistance in relapsed childhood cancer.
Australian researchers have made a breakthrough that could improve treatment for children with neuroblastoma, a aggressive cancer that currently proves fatal in 9 out of 10 young patients whose disease recurs. ()
Scientists at the Garvan Institute of Medical Research in Sydney, Australia, have identified a drug combination capable of bypassing the cellular defense mechanisms that these tumors develop, which typically allow them to resist standard therapies and lead to relapse. This discovery opens the door to potentially more effective treatment strategies for high-risk pediatric patients.
TOP INSIGHT
A promising path for #neuroblastoma treatment! Romidepsin’s existing approval for other cancers and established pediatric safety profile could speed its clinical development. While promising, further rigorous #clinicaltrials are essential to confirm its safety and efficacy for neuroblastoma patients. #ChildhoodCancer #Romidepsin #NewTreatment
Existing Cancer Drug Triggers Alternative Cell Death Pathway in Neuroblastoma
In findings made in animal models and published in Science Advances, Associate Professor David Croucher and his team have shown that a drug already approved for other cancers can trigger neuroblastoma cell death through alternative pathways when the usual routes become blocked. This discovery could lead to better treatment strategies for children whose cancers have stopped responding to standard chemotherapy.
Neuroblastoma is the most common solid tumor in children outside the brain, developing from nerve cells in the adrenal glands above the kidneys or along the spine, chest, abdomen or pelvis. It is typically diagnosed in children under two years old. While those with low-risk disease have excellent outcomes, around half of patients are diagnosed with high-risk neuroblastoma – an aggressive form where tumor’s have already spread. Of these high-risk patients, 15 percent don’t respond to initial treatment, and half of those who do respond will see their cancer return.
The researchers first investigated why neuroblastoma becomes resistant to treatment. They studied lab-grown neuroblastoma cells and compared tumor samples from the same children at diagnosis and after their cancer returned. This allowed them to track changes that occur as the cancer develops resistance.
They discovered that many standard chemotherapy drugs rely on the same cellular ‘switch’ called the JNK pathway, to trigger cancer cell death. In relapsed tumors, this switch has often stopped working, meaning treatments are no longer effective.
“Finding a way to overcome the resistant state of relapsed high-risk neuroblastomas has been a major goal for my lab,” says Associate Professor Croucher. “These tumors can be highly resistant to chemotherapy – and the statistics once patients get to that point are devastating for families. By finding drugs that don’t depend on the JNK pathway, we can still trigger cancer cell death even when this usual route is blocked.”
FDA-Approved Lymphoma Drug (Romidepsin) Identified as Potent Against Neuroblastoma
Looking for treatments that don’t rely on this cellular switch to induce cell death, the team then screened a large collection of FDA-approved drugs with pediatric safety data, aiming to find those that could be rapidly adopted for clinical use. They identified romidepsin, a drug currently used to treat certain lymphomas, as particularly potent against neuroblastoma cells whether or not the JNK pathway is working.
Through collaboration with the Children’s Cancer Institute, the team used animal models of relapsed neuroblastoma to test whether adding romidepsin to standard chemotherapy could overcome the resistance.
In their models, they found that the new combination reduced tumor growth and extended survival time compared to standard treatment alone, indicating lower resistance to treatment. Also, in combination with romidepsin, lower doses of standard chemotherapy achieved the same cancer-killing effect as higher doses of chemotherapy alone. This raises the possibility of reduced side effects in future treatment – an important consideration when treating young children.
While the lab results are encouraging, Associate Professor Croucher says that more research is needed before these findings can be translated into patient care. His team is now focused on optimizing the combination treatment schedules and delivery methods for safety and effectiveness.
“This represents a big step forward, but the next challenge will be working on getting these findings into the clinic,” says Associate Professor Croucher. “We’re using this data as proof of principle to develop the best ways to deliver these treatments.”
Romidepsin’s Existing Safety Data Could Accelerate New Neuroblastoma Treatment Development
Romidepsin is already approved for use in other cancers and has been tested for safety in children, which could potentially accelerate the development of the drug as a new treatment option for neuroblastoma. However, any clinical application requires further testing and clinical trials to establish the combination’s safety and efficacy in neuroblastoma.
“Behind every statistic is someone’s loved one,” says Associate Professor Croucher. “Understanding these molecular mechanisms gives us hope we can develop more effective treatments for patients and their families who currently face limited options – and that’s what drives us every day.”
References:
- Inclusion of JNK-independent drugs within multi-agent chemotherapy improves response in relapsed high-risk neuroblastoma – (https://www.science.org/doi/10.1126/sciadv.ady5599)
Source-Eurekalert