A genetic mutation found in two human patients with schizophrenia also increased schizophrenia-related behaviors in mice with the same mutation, a rare finding of a direct genetic link to psychosis, report researchers at the University of Illinois Urbana-Champaign and colleagues in Massachusetts and Germany.
The mutation increases levels of glycine decarboxylase, or GLDC, an enzyme responsible for regulating glycine in the brain. Glycine activates receptors for the neurotransmitter glutamate, called NDMA receptors.
"The genetics of schizophrenia is very complex, and it is rare that mutations found in patients can be...
Fighting stigma about schizophrenia – with Michelle Hammer
Content warning:
This episode discusses suicidality, paranoia, hallucinations and delusions, and mentions drug use and homelessness. Michelle...
Summary: A new study links hallucinogen-related emergency department visits to a 21-fold increased risk of schizophrenia compared to the general population. Even after...
Summary: New research highlights neuroglia (or glia cells) as critical players in mental health, potentially influencing conditions like depression and schizophrenia. Glia cells,...
