A genetic mutation found in two human patients with schizophrenia also increased schizophrenia-related behaviors in mice with the same mutation, a rare finding of a direct genetic link to psychosis, report researchers at the University of Illinois Urbana-Champaign and colleagues in Massachusetts and Germany.
The mutation increases levels of glycine decarboxylase, or GLDC, an enzyme responsible for regulating glycine in the brain. Glycine activates receptors for the neurotransmitter glutamate, called NDMA receptors.
"The genetics of schizophrenia is very complex, and it is rare that mutations found in patients can be...
Summary: Researchers have identified a brain biomarker that may predict psychosis onset before symptoms appear, enabling earlier interventions and personalized care. MRI scans...
Summary: A new study identifies previously hidden brain network patterns in schizophrenia by focusing on nonlinear connectivity, offering potential biomarkers for early diagnosis....
