Summary: Researchers identified a rare genetic mutation in two schizophrenia patients that increased schizophrenia-related behaviors in mice. The mutation led to higher levels of glycine decarboxylase (GLDC), an enzyme that degrades glycine, reducing NMDA receptor activation.Mice with extra copies of the GLDC gene exhibited schizophrenia-like behaviors, confirming its role in the condition. Advanced brain analysis showed that available glycine was significantly lower in a specific brain region, disrupting neural signaling.Key Facts:Genetic Link: Extra copies of the GLDC gene led to schizophrenia-like behaviors in mice.Brain Disruption: The mutation lowered...
Summary: Scientists have identified how genetic variants influence the risk of neurological and psychiatric disorders, including schizophrenia and autism. Using live neural cells...
Auditory hallucinations are likely the result of abnormalities in two brain processes: a "broken" corollary discharge that fails to suppress self-generated sounds, and...
Summary: A new study reveals that auditory hallucinations in schizophrenia may be caused by two faulty brain processes: a failed suppression of self-generated...
Summary: Neuroscientists have discovered how the CP-AMPA receptor in brain cells influences neuron selectivity in response to sensory stimuli. This receptor type makes...
