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In this podcast, neuroscientist Lisa Mosconi explores how hormonal changes during menopause influence women’s brain health and Alzheimer’s risk, highlighting advances in brain imaging, hormone therapy, and emerging treatments. She emphasizes the need for sex-specific research, personalized interventions, and lifestyle factors while introducing the CARE initiative aimed at improving prevention and care for women’s cognitive aging.
00:00 Introduction
00:46 Lisa Mosconi’s Background and Personal Connection
01:28 Overview of Dementia Types and Sex Differences in Prevalence
02:24 Brain Imaging Techniques Used in Alzheimer’s and Hormonal Research
03:15 Novel PET Imaging of Estrogen Receptors in the Brain
04:06 Hormonal Changes During Menopause and Brain Impact
04:50 Hormone Replacement Therapy (HRT): Timing, Formulations, and Effects
06:01 Nuances of Estrogen Receptor Function and Therapeutic Potential
06:43 Selective Estrogen Receptor Modulators (SERMs) and PhytoSERMs
07:24 The Role and Misconceptions of Estrogen in Cancer Risk
08:01 Challenges in Alzheimer’s Risk Modeling and Sex-Specific Data Gaps
08:38 The CARE Research Initiative
09:21 Hormonal Considerations in Women Undergoing Surgical Menopause
09:51 Lifestyle Factors and Alzheimer’s Prevention
10:30 GLP-1 Agonists and Potential Neuroprotection
11:11 Use of Biomarkers and Brain Scans in Clinical Practice
11:44 Final Advice for Women Concerned About Brain Health
This video is a podcast summary of The Peter Attia Drive Podcast episode titled ‘381‒Alzheimer’s disease in women: how hormonal transitions impact the brain, new therapies, & more’.
Link:
Publish date: Jan 26, 2026
Summary article:
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