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What is Alzheimer disease? Alzheimer disease, often called Alzheimer’s disease by the public, is a neurodegenerative disease that leads to symptoms of dementia. Progression of Alzheimer disease is thought to involve an accumulation of beta-amyloid plaque and neurofibrillary tangles in the brain. This video covers the mechanisms and pathophysiology thought to contribute to Alzheimer disease, including a definitions of sporadic as well as familial Alzheimer disease, common signs and symptoms, and diagnosis.
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